Acetohydrazide → HCID 22768948, compound

HRID 1764652Notes

Reaction equation

HRID 1764652 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)=[CH:6][C:7]=1[CH3:8].[C:16]([NH:19][NH2:20])(=O)[CH3:17]>C(O)CCC>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([C:5]2[CH:6]=[C:7]([CH3:8])[C:2]3[N:3]([C:16]([CH3:17])=[N:19][N:20]=3)[N:4]=2)=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 14039AcetohydrazideHCID 12449553HCID 12449553, compound

Product 1

HCID 22768948HCID 22768948, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A mixture of 1.0 g. of 3-chloro-6-(p-chlorophenyl)-4-methylpyridazine, 0.62 g. of acetic acid hydrazide and 10 ml. of n-butanol is refluxed for 48 hours. The solvent is removed and the residue dissolved in dichloromethane and filtered through magnesol. The solid from the filtrate is recrystallized from dichloromethane-hexane to give 0.6 g. of solid, m.p. 209°-212° C. Recrystallization from dichloromethane-hexane gives the product of the example as light pink colored crystals, m.p. 215°-217° C.

Workup

  1. additionA mixture of 1.0 g
  2. customThe solvent is removed
  3. dissolutionthe residue dissolved in dichloromethane
  4. filtrationfiltered through magnesol
  5. customThe solid from the filtrate is recrystallized from dichloromethane-hexane
  6. customto give 0.6 g
  7. customRecrystallization from dichloromethane-hexane
  8. customgives the product of the example as light pink colored crystals, m.p. 215°-217° C.

Sources & evidence

ORD record
ord-1f78e2685bf24603b720309b15a0640e
Source dataset
uspto-grants-1978_09
Patent number
US04117130

Reaction notes

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