Hydrazinecarboxaldehyde → HCID 12726832, compound

HRID 1764653Notes

Reaction equation

HRID 1764653 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1.[CH:18]([NH:20][NH2:21])=O>C(O)CCC>[F:15][C:14]([F:17])([F:16])[C:11]1[CH:12]=[CH:13][C:8]([C:5]2[CH:6]=[CH:7][C:2]3[N:3]([CH:18]=[N:20][N:21]=3)[N:4]=2)=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 12229HydrazinecarboxaldehydeHCID 12449554Pyridazine, 3-chloro-6-[4-(trifluoromethyl)phenyl]-

Product 1

HCID 12726832HCID 12726832, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A mixture of 4.50 g. of 3-chloro-6-(α,α,α-trifluoro-p-tolyl)pyridazine, 2.09 g. of formylhydrazine and 100 ml. of n-butanol is stirred and refluxed for 3 days. The solvent is removed and the residue dissolved in methylene chloride, passed through magnesol and the solid from the filtrate recrystallized from methylene chloride/hexane to afford the product as white crystals, m.p. 160°-161° C.

Workup

  1. additionA mixture of 4.50 g
  2. temperaturerefluxed for 3 days
  3. customThe solvent is removed
  4. dissolutionthe residue dissolved in methylene chloride
  5. customthe solid from the filtrate recrystallized from methylene chloride/hexane

Sources & evidence

ORD record
ord-0dd1fdaf53764d5c8320e74325e8e92c
Source dataset
uspto-grants-1978_09
Patent number
US04117130

Reaction notes

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