1,3-Dibromopropane → HCID 22768839, compound

Participants

Reaction Steps

To a solution of 0.85 g. (0.0024 mol.) of 3-(4-hydroxyphenylsulfonyl)-2-phenylbenzofuran in 25 ml. of dry acetone was added 0.96 g. (0.0048 mol.) of 1,3-dibromopropane and 0.66 g. (0.0048 mol.) of potassium carbonate. The mixture was refluxed for ca. 12 hours, then an additional 0.4 g. of 1,3-dibromopropane, 0.3 g. of potassium carbonate and 25 ml. of dry acetone were added and the mixture was refluxed for 5 hours. The reaction mixture was filtered and the solvent was removed in vacuo to give a residue which was dissolved in 2-4 ml. of ethanol to which 22-24 ml. of freshly distilled di-n-butylamine was added. The mixture was heated at 130° for 4 hours, then cooled and diluted with ethanol. The solvent and excess amine were removed by evaporation to give 0.23 g. of the title compound.

Provenance & Evidence