4-Methoxybenzenesulfonyl chloride → 5-Chloro-3-(4-hydroxyphenylsulfonyl)-2-phenylbenzofuran

HRID 1764667Notes

Reaction equation

HRID 1764667 reaction equation
ClC1C=CC2OC(C3C=CC=CC=3)=CC=2C=1.COC1C=CC(S(Cl)(=O)=O)=CC=1.[Cl:29][C:30]1[CH:31]=[CH:32][C:33]2[O:37][C:36]([C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=3)=[C:35]([S:44]([C:47]3[CH:52]=[CH:51][C:50]([O:53]C)=[CH:49][CH:48]=3)(=[O:46])=[O:45])[C:34]=2[CH:55]=1>>[Cl:29][C:30]1[CH:31]=[CH:32][C:33]2[O:37][C:36]([C:38]3[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=3)=[C:35]([S:44]([C:47]3[CH:52]=[CH:51][C:50]([OH:53])=[CH:49][CH:48]=3)(=[O:46])=[O:45])[C:34]=2[CH:55]=1

Participants

4

Reactant 3

HCID 74014-Methoxybenzenesulfonyl chlorideHCID 6150425-Chloro-2-phenylbenzofuranHCID 227688495-Chloro-3-(4-methoxyphenylsulfonyl)-2-phenylbenzofuran

Product 1

HCID 227689115-Chloro-3-(4-hydroxyphenylsulfonyl)-2-phenylbenzofuran

Procedure

Acylation of 5-chloro-2-phenylbenzofuran with 4-methoxybenzenesulfonyl chloride as described in Example 1 followed by demethylation of the 5-chloro-3-(4-methoxyphenylsulfonyl)-2-phenylbenzofuran thus formed also as described therein, gives 5-chloro-3-(4-hydroxyphenylsulfonyl)-2-phenylbenzofuran.

Workup

  1. customthus formed also

Sources & evidence

ORD record
ord-6aba06c17ba74442b679d4d84f2f24c2
Source dataset
uspto-grants-1978_09
Patent number
US04117128

Reaction notes

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