Methanesulfonyl chloride → 2-Benzamidoethyl methanesulfonate

HRID 1764866Notes

Reaction equation

HRID 1764866 reaction equation
[OH:1][CH2:2][CH2:3][NH:4][C:5](=[O:12])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[CH3:13][S:14](Cl)(=[O:16])=[O:15]>>[CH3:13][S:14]([O:1][CH2:2][CH2:3][NH:4][C:5](=[O:12])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)(=[O:16])=[O:15]

Participants

3

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 5695262-Benzamidoethanol

Product 1

HCID 227357142-Benzamidoethyl methanesulfonate

Procedure

2-Benzamidoethyl methanesulfonate was prepared by following the general procedure of Example 43 for mesylation as a colorless oil (291 mg, 84%) from N-(2-hydroxyethyl) benzamide (245 mg, 1.30 mmol) and methanesulfonyl chloride (223 mg, 1.94 mmol). 1H NMR (CDCl3, 300 MHz) δ2.85 (s, 3H), 4.48 (t, 2H, J=9.5 Hz), 5.10 (t, 2H, J=10.2 Hz), 7.58-7.63 (m, 2H), 7.74-7.80 (m, 1H), 8.20-8.23 (m, 2H) ppm.

Sources & evidence

ORD record
ord-9013bcd966434b069e31a4f5be5fb301
Source dataset
uspto-grants-2007_06
Patent number
USRE039679E1

Reaction notes

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