Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Purine | HCID 1044 | — |
| Reactant | 1-Bromo-3-chloropropane | HCID 8006 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 9-(3-Chloropropyl)purine | HCID 22715671 | 68% |
| Product | HCID 22735881 | HCID 22735881 | 23% |
Reaction Steps
To a solution of purine (360 mg, 3.00 mmol) and 1-bromo-3-chloropropane (1.42 g, 9.0 mmol) in DMF (10 mL) was added K2CO3 (622 mg, 4.5 mmol) at 20° C. The reaction mixture was stirred for 24 h at 20° C. and filtered. The filtrate was concentrated in vacuo and the residue was chromatographed to give 9-(3-chloropropyl)purine (400 mg, 68%) and 7-(3-chloropropyl)purine (136 mg, 23%) as colorless oils.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | USRE039679E1 |
|---|
| Source dataset | uspto-grants-2007_06 |
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| ORD ID | ord-160973f74e634132a5094370fef6f383 |
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| Source note | uspto-grants-2007_06 |
|---|
