5-(Methoxymethyl)-2-nitrophenol → HCID 23112756, compound

Participants

Reaction Steps

A solution of 2 (20 g, 108 mmol) in EtOH (300 mL) was hydrogenated over PtO2 (300 mg) in Parr pressure apparatus until the theoretical amount of hydrogen was absorbed. The catalyst was removed by filtration through a pad of Celite, and the filtrate was concentrated in vacuo to a solid (21 g, 100%). This solid was combined with material obtained from a smaller run then passed through a pad of silica gel (500 g) eluted with ether. Fractions containing pure product were combined, dried then concentrates, yield 20 g (89%) m.p. 108–108.5° C. (uncorrected).

Provenance & Evidence