HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1764960Generated: November 1, 2026
tert-Butyldimethylsilyl chloride → HCID 69410951, compound
https://huagongshe.com/reaction/1764960
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | HCID 69411353 | HCID 69411353 | — |
| Solvent | Imidazole | HCID 795 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 69410951 | HCID 69410951 | 91.5% |
Reaction Steps
3β-Hydroxy-4,4-dimethyl-5α-chola-8,14-dien-24-oic acid methyl ester (18.0 g) is suspended in 300 ml of DMF and 14.8 g of imidazol, and 13 g of tert-butyldimethylsilylchloride is added. The reaction mixture is stirred at 70° C. for 20 hours. After aqueous work-up, and crystallisation from diethyl ether/methanol, 21.0 g of 3β-tert-butyldimethylsilyloxy-4,4-dimethyl-5α-chola-8,14-dien-24-oic acid methyl ester is isolated. Melting point, 124-125° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | USRE039678E1 |
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| Source dataset | uspto-grants-2007_06 |
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| ORD ID | ord-895bae60ce9745b9a0b5c0ba5550ffca |
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| Source note | uspto-grants-2007_06 |
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