Imidazole → tert-Butyl(2-iodoethoxy)dimethylsilane

Participants

Reaction Steps

To a solution of 2-iodoethanol (3 g, 17 mmol) and imidazole (1.74 g, 25 mmol) in 20 mL anhydrous dichloromethane was added TBSCl (2.82 g, 18.7 mmol). The mixture was stirred at room temperature overnight (12 hours). The reaction mixture was washed with water (2×10 mL), brine (10 mL) and dried over Na2SO4. Removal of the solvent afforded pure product I(CH2)2OTBS (1) (5.6 g, 98% yield, MW: 286.02).

Provenance & Evidence