HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 1-Ethynyl-2,3,4-trifluorobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-Methyl-4-(2,3,4-trifluorophenyl)but-3-yn-2-ol | HCID 23115722 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 1-Ethynyl-2,3,4-trifluorobenzene | HCID 23115721 | 65.9% |
Reaction Steps
23 g of sodium hydroxide was added to 229 g of 1-(3-methyl-3-hydroxy-1-butynyl)-2,3,4-trifluorobenzene, and then stirred for 1 hour at 120° C., while acetone that is produced is distilled off using an atmospheric distillation device. This was purified by distillation under a reduced pressure (101 to 108° C./34 kPa (256 mmHg)) to obtain 110 g of 1-ethynyl-2,3,4-trifluorobenzene as an almost colorless oily material.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07226644B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-a28bf74bd25a4679a278d070d6e070f0 |
| Source note | uspto-grants-2007_06 |