1-(2,3,4-Trifluorophenyl)hept-1-YN-3-OL → 1-(3-Hydroxyheptyl)-2,3,4-trifluorobenzene

Participants

Reaction Steps

In 730 mL of ethyl acetate, 183 g of 1-(3-hydroxy-1-heptynyl)-2,3,4-trifluorobenzene was dissolved, and 9 g of 5% palladium carbon (50% in water) was added. Then, the mixutre was stirred for 6 hours at a hydrogen pressure of 0.4 MPa. After the catalyst was removed by filtration (using cellulose), the solvent was evaporated under a reduced pressure to obtain 170 g of 1-(3-hydroxyheptyl)-2,3,4-trifluorobenzene as a light yellow solid.

Provenance & Evidence