Hydrochloric Acid → HCID 178465827, compound

Participants

Reaction Steps

The DMF (100 ml) suspension containing 2-(trans-4-ethylcyclohexyl)-7,8-difluoro-6-hydroxychroman (28 g), iodoethane (25 g), and anhydrous potassium carbonate (15 g) was heated to reflux for 2 hours. The reaction solution was poured into 5% hydrochloric acid, extracted with toluene, and concentrated. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=9:1) to obtain 6-ethoxy-2-(trans-4-ethylcyclohexyl)-7,8-difluorochroman (30 g). Moreover, this was recrystallized using acetone to obtain 26 g of a pure substance.

Provenance & Evidence