反应详情

Acetic anhydride (0.92 mL, 8.25 mmol) and pyridine (0.2 mL, 2.5 mmol) were added to a solution of 5.3 (250 mg, 1.65 mmol) in 25 mL ether. The reaction was allowed to stir at ambient temperature for 24 hours. Water was added to the reaction and the organic was further extracted with 10% NaHCO3. The organic layer was dried with MgSO4 and evaporated. The residue was chromatographed on silica gel with EtOAc-Hexanes (5:95) to yield 5.6 (47%).

1. extractionthe organic was further extracted with 10% NaHCO3
2. dry with materialThe organic layer was dried with MgSO4
3. customevaporated
4. customThe residue was chromatographed on silica gel with EtOAc-Hexanes (5:95)