Sodium Hydroxide → HCID 58883234, compound

HRID 1765040Notes

Reaction equation

HRID 1765040 reaction equation
C[O:2][C:3](=[O:23])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[O:11][C:12]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[CH:13][C:14](=[O:16])[CH:15]=2)[CH:5]=1.[OH-].[Na+:25]>CO>[Na+:25].[N:17]1([C:12]2[O:11][C:10]([C:6]3[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=3)[C:3]([O-:23])=[O:2])=[CH:15][C:14](=[O:16])[CH:13]=2)[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 16203592HCID 16203592, compound

Product 1

HCID 58883234HCID 58883234, compoundYield 83.33%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3-(6-Morpholin-4-yl-4-oxo-4H-pyran-2-yl)-benzoic acid methyl ester (5.42 g, 17.20 mmol) was dissolved in methanol (25 ml) and sodium hydroxide (0.75 g, 18.90 mmol) was added. The stirred solution was then refluxed under nitrogen for three hours. The methanol was removed in vacuo and the residue was triturated in ether to give the title compound as a brown solid (4.30 g, 83.33%). m/z (LC-MS, ESP): 301 (M++1).

Workup

  1. temperatureThe stirred solution was then refluxed under nitrogen for three hours
  2. customThe methanol was removed in vacuo
  3. customthe residue was triturated in ether

Sources & evidence

ORD record
ord-0f31385246f143f7b2e00f4eb2348b0f
Source dataset
uspto-grants-2007_06
Patent number
US07226918B2

Reaction notes

Loading…