Sodium Hydroxide → HCID 58883240, compound

HRID 1765042Notes

Reaction equation

HRID 1765042 reaction equation
C[O:2][C:3](=[O:23])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:11][C:12]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[CH:13][C:14](=[O:16])[CH:15]=2)=[CH:6][CH:5]=1.[OH-].[Na+:25]>CO>[Na+:25].[N:17]1([C:12]2[O:11][C:10]([C:7]3[CH:8]=[CH:9][C:4]([C:3]([O-:23])=[O:2])=[CH:5][CH:6]=3)=[CH:15][C:14](=[O:16])[CH:13]=2)[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 16203593HCID 16203593, compound

Product 1

HCID 58883240HCID 58883240, compoundYield 97.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-(6-Morpholin-4-yl-4-oxo-4H-pyran-2-yl)-benzoic acid methyl ester (3.00 g, 9.52 mmol) was dissolved in methanol (20 ml) and sodium hydroxide (0.381 g, 9.52 mmol) was added. The stirred solution was then refluxed under nitrogen for three hours. The methanol was removed in vacuo and the residue was triturated in ether to give the title compound as a brown solid (3 g, 97%). m/z (LC-MS, ESP): 301 (M++1).

Workup

  1. temperatureThe stirred solution was then refluxed under nitrogen for three hours
  2. customThe methanol was removed in vacuo
  3. customthe residue was triturated in ether

Sources & evidence

ORD record
ord-307cba61d93c4b85b93420e1061b7638
Source dataset
uspto-grants-2007_06
Patent number
US07226918B2

Reaction notes

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