Morpholine → HCID 11493308, compound

HRID 1765048Notes

Reaction equation

HRID 1765048 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][C:7](SCC)=[CH:6][C:5]2=[O:15].[NH:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][C:7]([N:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1)=[CH:6][C:5]2=[O:15]

Participants

3

Reactant 2

HCID 8083MorpholineHCID 115872976-bromo-2-ethylsulfanyl-chromen-4-one

Product 1

HCID 11493308HCID 11493308, compound

Procedure

Prepared from 6-Bromo-2-ethylsulfanyl-chromen-4-one (0.375 g, 1.35 mmol) and morpholine (0.54 ml, 6.25 mmol), affording a pale yellow solid. (0354 g, 1.14 mmol, 84%); m.p. 147-149° C.; ES+(m/e)=310.24 (M++1); (200 MHz, CDCl3) δ 3.44 (4H, m); 3.77 (4H, m); 5.42 (1H, s); 7.11 (1H, d); 7.57 (1H, dd); 8.20 (1H, d)

Workup

  1. customaffording a pale yellow solid

Sources & evidence

ORD record
ord-720cd6e4dcf146729552928dc50129af
Source dataset
uspto-grants-2007_06
Patent number
US07226918B2

Reaction notes

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