HCID 21106684, compound → HCID 21106654, compound

Participants

Reaction Steps

A solution of N-(2-{[3-(2-(tetrahydro-2H-pyran-2-yloxy)ethoxy)pyridin-2-yl]methoxy}ethyl)-N,N-dimethylamine (from Step 3; 0.69 g, 2.13 mmol) in 2 M HOAc (20 mL) was stirred at 50° C. for two days. The reaction mixture was washed with CHCl3 (×3), saturated with sodium chloride, made basic by addition of 8 M NaOH, and extracted with CHCl3 (×3). The solvent from the combined organic phases was removed under reduced pressure to give 0.47 g (92%) of the title compound as a light brown oil. HRMS m/z calcd for C12H20N2O3 (M)+ 240.1474. found 240.1476.

Provenance & Evidence