Bromine → 2-(3-Bromo-8-fluoroimidazo[1,2-a]pyridin-7-yl)propan-2-ol

Participants

Role	Name	HCID	Charge
Reactant	Bromine	HCID 24408	—
Reactant	Potassium Bromide	HCID 253877	—
Reactant	Sodium Acetate	HCID 517045	—
Reactant	2-(8-Fluoroimidazo[1,2-a]pyridin-7-yl)propan-2-ol	HCID 44408729	—
Solvent	Methanol	HCID 887	—
Product	2-(3-Bromo-8-fluoroimidazo[1,2-a]pyridin-7-yl)propan-2-ol	HCID 67486910	45%

Reaction Steps

2-(8-Fluoroimidazo[1,2-α]pyridin-7-yl)propan-2-ol (1.00 g, 5.2 mmol) was brominated by treatment with bromine in methanol, in the presence of potassium bromide and sodium acetate, affording 2-(3-bromo-8-fluoroimidazo[1,2-α]pyridin-7-yl)propan-2-ol (637 mg, 45%): δH (360 MHz, CDCl3) 1.72 (6H, s), 7.32 (1H, t, J 6.9), 7.59 (1H, s), 7.89 (1H, d, J 7.3); m/z (ES+) 275 (100%, [M]+), 273 (100).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07226926B2
Source dataset	uspto-grants-2007_06
ORD ID	ord-f32dc1353d524965b024289d1052a99a
Source note	uspto-grants-2007_06