Lithium Hydroxide → HCID 21106878, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 8-(3-{1-[(1-tert-butoxycarbonyl-piperidin-4-yl)-methyl-amino]-cyclopropyl}-pyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid ethyl ester (15 g, 24 mmol) in ethanol (200 mL) was added the solution of LiOH (10 g, 238 mmol) in water (100 mL) in a round bottom flask. The solution was heated at 60° C. for one hour. The resulting solution was partitioned between dichloromethane (400 mL) and saturated aqueous NH4Cl (200 mL) and well shaken. The organic layer was separated, washed with brine, dried over sodium sulfate and concentrated in vacuo to yield a yellow solid (14 g). This was used without further purification.

Provenance & Evidence