Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(Trifluoromethoxy)aniline → 4-(3-Trifluoromethoxyanilino)-6-methyl-2-(2-pyridinyl)pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(Trifluoromethoxy)aniline | HCID 73753 | — |
| 반응물 | 4-Chloro-6-methyl-2-(pyridin-2-yl)pyrimidine | HCID 2763395 | — |
| 생성물 | 4-(3-Trifluoromethoxyanilino)-6-methyl-2-(2-pyridinyl)pyrimidine | HCID 22732353 | — |
반응 단계
The title compound was prepared from 4-chloro-6-methyl-2-(2-pyridinyl)pyrimidine (50 mg, 0.243 mmol) and 3-(trifluoromethoxy)aniline (65 μl, 0.243 mmol) similar to Example 11 and isolated as a pale white solid (78 mg, 93%). 1H NMR (DMSO-d6): 9.95 (s, 1H), 8.74 (s, 1H), 8.31 (d, J=9.3 Hz, 2H), 7.95 (t, J=7.7 Hz, 1H), 7.65 (d, J=8.4 Hz, 1H), 7.53–7.43 (m, 2H), 6.98 (d, J=8.4 Hz, 1H), 6.71 (s, 1H), 2.44 (s, 3H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07226927B2 |
| 출처 데이터셋 | uspto-grants-2007_06 |
| ORD ID | ord-eb354be4b342419ab7edbaab2e31d476 |
| 출처 메모 | uspto-grants-2007_06 |