Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,5-Dimethoxyaniline → 4-(2,5-Dimethoxyanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,5-Dimethoxyaniline | HCID 7613 | — |
| 반응물 | 4-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidine | HCID 1485990 | — |
| 생성물 | 4-(2,5-Dimethoxyanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine | HCID 10156358 | — |
반응 단계
The title compound was prepared from a mixture of 4-chloro-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine (100 mg, 0.385 mmol) and 2,5-dimethoxyaniline (59 mg, 0.385 mmol) similar to Example 13 and isolated as a greenish-yellow solid (24 mg, 17%). 1H NMR (CDCl3): 9.67–9.66 (m, 1H), 8.74–8.70 (m, 2H), 8.02 (s, 1H), 7.44–7.39 (m, 1H), 6.91 (s, 1H), 7.67 (s, 1H), 6.87 (d, J=8.7 Hz, 1H), 6.65 (dd, J=3.0, 9.0 Hz, 1H), 3.86 (d, J=7.2 Hz, 6H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07226927B2 |
| 출처 데이터셋 | uspto-grants-2007_06 |
| ORD ID | ord-c9381f8b42324ee1bc22f0cf969b97d3 |
| 출처 메모 | uspto-grants-2007_06 |