HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Dimethoxyaniline → 4-(2,5-Dimethoxyanilino)-2-(4-pyridinyl)-6-(trifluoromethyl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Dimethoxyaniline | HCID 7613 | — |
| Reactant | 4-Chloro-2-(pyridin-4-yl)-6-(trifluoromethyl)pyrimidine | HCID 1485989 | — |
| Product | 4-(2,5-Dimethoxyanilino)-2-(4-pyridinyl)-6-(trifluoromethyl)pyrimidine | HCID 22732411 | — |
Reaction Steps
The title compound was prepared from a mixture of 4-chloro-2-(4-pyridinyl)-6-(trifluoromethyl)pyrimidine (50 mg, 0.193 mmol) and 2,5-dimethoxyaniline (32 mg, 0.193 mmol) similar to Example 13 and isolated as a light tan solid (15 mg, 21%). 1H NMR (CDCl3): 8.79 (dd, J=1.8, 4.8 Hz, 2H), 8.31 (dd, J=1.8, 4.8 Hz, 2H), 8.02 (bs, 1H), 7.59 (s, 1H), 6.98 (s, 1H), 6.90 (d, J=9.0 Hz, 1H), 6.69 (dd, J=2.9, 9.2 Hz, 1H), 3.90 (s, 3H), 3.87 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07226927B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-892f5f61b7be4dc5ad379820e1bb44cb |
| Source note | uspto-grants-2007_06 |