1,3-Benzodioxol-5-amine → HCID 10155412, compound

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Reaction Steps

The title compound was prepared from a mixture of 4-chloro-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine (50 mg, 0.193 mmol) and 3,4-methylenedioxyaniline (53 mg, 0.386 mmol) similar to Example 58 and isolated as a light brown solid (37 mg, 53%). 1H NMR (CDCl3): 9.63 (dd, J=0.9, 1.8 Hz, 1H), 8.73–8.68 (m, 2H), 7.43–7.39 (m, 1H), 6.93 (s, 1H), 6.88 (d, J=8.1 Hz, 2H), 6.83 (dd, J=1.8, 8.1 Hz, 1H), 6.77 (s, 1H), 6.06 (s, 2H).

Provenance & Evidence