6-Chloro-m-anisidine → 4-(2-Chloro-5-methoxyanilino)-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine

Participants

Reaction Steps

The title compound was prepared from a mixture of 4-chloro-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine (25 mg, 0.096 mmol) and 2-chloro-5-methoxyaniline (23 mg, 0.144 mmol) similar to Example 92 and isolated as a white solid (11 mg, 48%). 1H NMR (CDCl3): 8.84–8.82 (m, 1H), 8.58–8.54 (m, 1H), 7.90–7.85 (m, 1H), 7.66 (s, 1H), 7.60 (s, 1H), 7.46–7.41 (m, 1H), 7.37 (d, J=8.7 Hz, 1H), 7.01 (s, 1H), 6.75 (dd, J=3.0, 8.7 Hz, 1H), 3.88 (s, 3H).

Provenance & Evidence