Benzenamine, 3-(methylthio)- → HCID 22732368, compound

HRID 1765199Notes

Reaction equation

HRID 1765199 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[N:3]=1.[CH3:18][S:19][C:20]1[CH:21]=[C:22]([CH:24]=[CH:25][CH:26]=1)[NH2:23]>>[CH3:18][S:19][C:20]1[CH:21]=[C:22]([CH:24]=[CH:25][CH:26]=1)[NH:23][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[N:3]=1

Participants

3

Reactant 2

HCID 15693Benzenamine, 3-(methylthio)-HCID 113115004-Chloro-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine

Product 1

HCID 22732368HCID 22732368, compound

Procedure

The title compound was prepared from a mixture of 4-chloro-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine (25 mg, 0.096 mmol) and 3-(methylmercapto)aniline (18 μl, 0.144 mmol) similar to Example 92 and isolated as a yellow solid (21 mg, 58%). 1H NMR (CDCl3): 8.87–8.85 (m, 1H), 8.58 (d, J=7.8 Hz, 1H), 7.93–7.88 (m, 1H), 7.61 (s, 1H), 7.48–7.44 (m, 1H), 7.36 (t, J=7.8 Hz, 1H), 7.25 (s, 1H), 7.17–7.14 (m, 1H), 7.10–7.06 (m, 1H), 7.01 (s, 1H), 2.52 (s, 3H).

Sources & evidence

ORD record
ord-f93684b28e1541e58757111aab1b2e0c
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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