3-Aminophenol → HCID 22732507, compound

HRID 1765202Notes

Reaction equation

HRID 1765202 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[N:3]=1.[NH2:18][C:19]1[CH:20]=[C:21]([OH:25])[CH:22]=[CH:23][CH:24]=1>>[ClH:1].[OH:25][C:21]1[CH:20]=[C:19]([CH:24]=[CH:23][CH:22]=1)[NH:18][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[N:3]=1

Participants

3

Reactant 2

HCID 115683-AminophenolHCID 14859894-Chloro-2-(pyridin-4-yl)-6-(trifluoromethyl)pyrimidine

Product 1

HCID 22732507HCID 22732507, compound

Procedure

The title compound was prepared from a mixture of 4-chloro-2-(4-pyridinyl)-6-(trifluoromethyl)pyrimidine (50 mg, 0.193 mmol), 3-aminophenol (32 mg, 0.290 mmol) similar to Example 97 and isolated as a yellow solid (37 mg, 52%). 1H NMR (DMSO-d6): 10.51 (s, 1H), 8.98 (d, J=6.0 Hz, 2H), 8.54 (d, J=6.6 Hz, 2H), 7.32–7.21 (m, 5H), 6.61–6.57 (m, 1H).

Sources & evidence

ORD record
ord-0850a990b7bb48d1938683108f19a77b
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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