4-Chloro-2-(pyridin-4-yl)-6-(trifluoromethyl)pyrimidine → HCID 10109502, compound

Participants

Reaction Steps

The title compound was prepared from a mixture of 4-chloro-2-(4-pyridinyl)-6-(trifluoromethyl)pyrimidine (50 mg, 0.193 mmol) and 2-chloro-5-hydroxyaniline (42 mg, 0.290 mmol) similar to Example 108 and isolated as a brown solid (3 mg, 4%). 1H NMR (CDCl3): 8.68 (dd, J=1.8, 4.5 Hz, 2H), 8.13 (dd, J=1.8, 4.2 Hz, 2H), 7.99 (d, J=2.7 Hz, 1H), 7.34 (s, 1H), 7.33 (d, J=8.7 Hz, 1H), 6.98 (s, 1H), 6.73 (dd, J=2.7, 8.7 Hz, 1H).

Provenance & Evidence