3,5-Dimethylaniline → HCID 22732515, compound

HRID 1765219Notes

Reaction equation

HRID 1765219 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1.[CH3:18][C:19]1[CH:20]=[C:21]([CH:23]=[C:24]([CH3:26])[CH:25]=1)[NH2:22]>>[CH3:18][C:19]1[CH:20]=[C:21]([CH:23]=[C:24]([CH3:26])[CH:25]=1)[NH:22][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1

Participants

3

Reactant 2

HCID 79493,5-DimethylanilineHCID 14859904-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidine

Product 1

HCID 22732515HCID 22732515, compound

Procedure

The title compound was prepared from a mixture of 4-chloro-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine (50 mg, 0.193 mmol) and 3,5-dimethylaniline (36 μl, 0.290 mmol) similar to Example 117 and isolated as a yellow solid (26 mg, 39%). 1H NMR (CDCl3): 9.66–9.64 (m, 1H), 8.73 (s, 1H), 8.72–8.69 (m, 1H), 7.44–7.40 (m, 1H), 7.30 (s, 1H), 7.04 (s, 2H), 6.93 (s, 1H), 6.90 (s, 1H), 2.38 (s, 3H), 2.37 (s, 3H).

Sources & evidence

ORD record
ord-48e78e1e0be94173a4139dac20773564
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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