2-Chloro-5-methylaniline → HCID 22732455, compound

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Reaction Steps

The title compound was prepared from a mixture of 4-chloro-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine (50 mg, 0.193 mmol) and 2-chloro-5-methylaniline (41 mg, 0.290 mmol) similar to Example 117 and isolated as a yellow solid (15 mg, 21%). 1H NMR (CDCl3): 9.62–9.61 (m, 1H), 8.73–8.69 (m, 2H), 7.89 (s, 1H), 7.44–7.40 (m, 1H), 7.37 (d, J=8.1 Hz, 1H), 7.30 (s, 1H), 7.00 (dd, J=0.9, 8.4 Hz, 1H), 6.88 (s, 1H), 2.42 (s, 3H).

Provenance & Evidence