4-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidine → HCID 22732354, compound

HRID 1765226Notes

Reaction equation

HRID 1765226 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1.[CH3:18][C:19]1[CH:20]=[C:21]([CH:23]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:25]=1)[NH2:22]>>[CH3:18][C:19]1[CH:20]=[C:21]([CH:23]=[C:24]([C:26]([F:27])([F:28])[F:29])[CH:25]=1)[NH:22][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1

Participants

3

Reactant 2

HCID 14859904-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidineHCID 27377133-Amino-5-methylbenzotrifluoride

Product 1

HCID 22732354HCID 22732354, compound

Procedure

The title compound was prepared from a mixture of 4-chloro-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine (50 mg, 0.193 mmol) and 3-methyl-5-(trifluoromethyl)aniline (51 mg, 0.290 mmol) similar to Example 117 and isolated as a yellow solid (60 mg, 78%). 1H NMR (DMSO-d6): 10.60 (s, 1H), 9.45–9.44 (m, 1H), 8.77–8.75 (m, 1H), 8.60–8.56 (m, 1H), 8.30 (s, 1H), 7.68 (s, 1H), 7.62–7.58 (m, 1H), 7.32 (s, 1H), 7.16 (s, 1H), 2.45 (s, 3H).

Sources & evidence

ORD record
ord-780ece279a5a41528950d9d6bc8b1394
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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