4-Amino-2,5-dimethylphenol → HCID 135794339, compound

HRID 1765243Notes

Reaction equation

HRID 1765243 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[N:3]=1.[NH2:18][C:19]1[C:24]([CH3:25])=[CH:23][C:22]([OH:26])=[C:21]([CH3:27])[CH:20]=1>>[ClH:1].[CH3:25][C:24]1[CH:23]=[C:22]([OH:26])[C:21]([CH3:27])=[CH:20][C:19]=1[NH:18][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[N:3]=1

Participants

3

Reactant 2

HCID 765444-Amino-2,5-dimethylphenolHCID 113115004-Chloro-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine

Product 1

HCID 135794339HCID 135794339, compound

Procedure

The title compound was prepared from a mixture of 4-chloro-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine (50 mg, 0.193 mmol) and 4-amino-2,5-dimethylphenol (40 mg, 0.290 mmol) similar to Example 117 and isolated as an orange solid (35 mg, 47%). 1H NMR (CDCl3): 8.79–8.77 (m, 1H), 8.58 (d, J=7.8 Hz, 1H), 8.14 (bs, 1H), 7.91–7.86 (m, 1H), 7.46–7.42 (m, 1H), 7.09 (bs, 1H), 6.92 (s, 1H), 6.83 (s, 1H), 6.46 (s, 1H), 2.22 (s, 3H), 2.02 (s, 3H).

Sources & evidence

ORD record
ord-17b30e40f46e45c9bd801035f52eb6df
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

Loading…