4-Amino-2,5-dimethylphenol → HCID 135794342, compound

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Reaction Steps

The title compound was prepared from a mixture of 4-chloro-(2-pyrazinyl)-6-(trifluoromethyl)pyrimidine (50 mg, 0.191 mmol) and 4-amino-2,5-dimethylphenol (39 mg, 0.287 mmol) similar to Example 117 and isolated as an orange solid (35 mg, 47%). 1H NMR (CDCl3): 9.75 (d, J=1.2 Hz, 1H), 8.79–8.78 (m, 1H), 8.73 (d, J=2.4 Hz, 1H), 7.20 (s, 1H), 7.01 (s, 1H), 6.78 (s, 1H), 6.52 (s, 1H), 5.43 (s, 1H), 2.25 (s, 3H), 2.16 (s, 3H).

Provenance & Evidence