4,5-Dimethoxy-2-methylaniline → HCID 22732516, compound

HRID 1765250Notes

Reaction equation

HRID 1765250 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[N:3]=1.[CH3:18][O:19][C:20]1[C:26]([O:27][CH3:28])=[CH:25][C:23]([NH2:24])=[C:22]([CH3:29])[CH:21]=1>>[ClH:1].[CH3:18][O:19][C:20]1[C:26]([O:27][CH3:28])=[CH:25][C:23]([NH:24][C:2]2[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]3[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=3)[N:3]=2)=[C:22]([CH3:29])[CH:21]=1

Participants

3

Reactant 2

HCID 2665854,5-Dimethoxy-2-methylanilineHCID 14859894-Chloro-2-(pyridin-4-yl)-6-(trifluoromethyl)pyrimidine

Product 1

HCID 22732516HCID 22732516, compound

Procedure

The title compound was prepared from a mixture of 4-chloro-2-(4-pyridinyl)-6-(trifluoromethyl)pyrimidine (50 mg, 0.193 mmol) and 4,5-dimethoxy-2-methylaniline (48 mg, 0.290 mmol) similar to Example 117 and isolated as a brown solid (23 mg, 30%). 1H NMR (CDCl3): 9.54 (dd, J=1.5, 4.5 Hz, 2H), 9.05 (dd, J=1.5, 4.5 Hz, 2H), 7.98 (s, 1H), 7.60 (s, 2H), 7.29 (s, 1H), 4.71 (s, 3H), 4.63 (s, 3H), 3.00 (s, 3H).

Sources & evidence

ORD record
ord-f0196d5f100346ba8e61ca22e155f637
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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