2-Amino-4-chloro-6-methylpyrimidine → HCID 22732447, compound

HRID 1765251Notes

Reaction equation

HRID 1765251 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([CH3:9])[N:3]=1.Cl.[Cl:11][C:12]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][C:13]=1[NH2:14]>>[Cl:11][C:12]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][C:13]=1[NH:14][C:6]1[CH:5]=[C:4]([CH3:9])[N:3]=[C:2]([NH2:1])[N:7]=1

Participants

3

Reactant 2

HCID 218102-Amino-4-chloro-6-methylpyrimidineHCID 27239002-Chloro-5-methoxyanilinium chloride

Product 1

HCID 22732447HCID 22732447, compound

Procedure

The title compound was prepared from a mixture of 2-amino-4-chloro-6-methyl-pyrimidine (100 mg, 0.696 mmol) and 2-chloro-5-methoxyaniline hydrochloride (203 mg, 1.05 mmol) similar to Example 117 and isolated as a white solid (132 mg, 72%). 1H NMR (CDCl3): 7.77 (d, J=2.7 Hz, 1H), 7.28 (d, J=9.0 Hz, 6.74 (s, 1H), 6.57 (dd, J=3.0, 8.7 Hz, 1H), 6.04 (s, 1H), 4.81 (s, 2H), 3.82 (s, 3H), 2.26 (s, 3H).

Sources & evidence

ORD record
ord-0833211efd804d42b8aaebd508fb8ce0
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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