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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1765254Generated: October 29, 2026

4-Chloro-2,5-dimethoxyaniline → HCID 22732503, compound

https://huagongshe.com/reaction/1765254

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Chloro-2,5-dimethoxyanilineHCID 22833—
Reactant4-Chloro-2-(pyridin-4-yl)-6-(trifluoromethyl)pyrimidineHCID 1485989—
ProductHCID 22732503HCID 22732503—

Reaction Steps

The title compound was prepared from a mixture of 4-chloro-2-(4-pyridinyl)-6-(trifluoromethyl)pyrimidine (50 mg, 0.193 mmol) and 4-chloro-2,5-dimethoxyaniline (54 mg, 0.290 mmol) similar to Example 117 and isolated as a brown solid (55 mg, 68%). 1H NMR (CDCl3): 8.78 (dd, J=1.8, 4.8 Hz, 2H), 8.31 (dd, J=1.8, 4.8 Hz, 2H), 8.24 (s, 1H), 7.52 (s, 1H), 7.01 (s, 1H), 6.96 (s, 1H), 3.98 (s, 3H), 3.91 (s, 3H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07226927B2
Source datasetuspto-grants-2007_06
ORD IDord-0224889b93ac46e3b606465ffffb14e8
Source noteuspto-grants-2007_06