Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1765258Generated: October 31, 2026

5-Chloro-2-methoxyaniline → HCID 22732360, compound

https://huagongshe.com/reaction/1765258

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Chloro-2-methoxyanilineHCID 66763—
Reactant4-Chloro-2-(pyridin-4-yl)-6-(trifluoromethyl)pyrimidineHCID 1485989—
ProductHCID 22732360HCID 22732360—

Reaction Steps

The title compound was prepared from 4-chloro-2-(4-pyridinyl)-6-trifluoromethyl-pyrimidine (150 mg, 0.578 mmol) and 5-chloro-2-methoxyaniline (98 mg, 0.621 mmol) similar to Example 160 and was isolated as off-white solid (84 mg, 0.221 mmol, 38%). 1H NMR (CDCl3/MeOH-d4): 8.72 (d, J=4.2 Hz, 2H), 8.51 (s, 1H), 8.34 (d, J=4.5 Hz), 7.09 (m, 2H), 6.91 (d, J=8.4 Hz, 1H), 3.93 (s, 3H)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07226927B2
Source datasetuspto-grants-2007_06
ORD IDord-83fff85e28ba43029d0110a344688276
Source noteuspto-grants-2007_06