5-Methoxy-2-methyl-4-nitroaniline → HCID 22732373, compound

HRID 1765262Notes

Reaction equation

HRID 1765262 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1.[CH3:18][O:19][C:20]1[C:21]([N+:28]([O-:30])=[O:29])=[CH:22][C:23]([CH3:27])=[C:24]([CH:26]=1)[NH2:25]>>[CH3:18][O:19][C:20]1[C:21]([N+:28]([O-:30])=[O:29])=[CH:22][C:23]([CH3:27])=[C:24]([CH:26]=1)[NH:25][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1

Participants

3

Reactant 2

HCID 6027265-Methoxy-2-methyl-4-nitroanilineHCID 14859904-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidine

Product 1

HCID 22732373HCID 22732373, compound

Procedure

The title compound was prepared from 4-chloro-2-(3-pyridinyl)-6-trifluoromethyl-pyrimidine (48 mg, 0.185 mmol) and 5-methoxy-2-methyl-4-nitroaniline (35 mg, 0.192 mmol) similar to Example 166 and was isolated as a white solid (mp 128–132° C., 11 mg, 0.027 mmol, 15%). 1H NMR (CDCl3): 9.62 (s, 1H), 8.68 (m, 2H), 7.79 (s, 1H), 7.73 (s, 1H), 7.48 (m, 1H), 7.01 (s, 1H), 4.02 (s, 3H), 2.63 (s, 1H).

Sources & evidence

ORD record
ord-63246fa9c3c74ebfaf945f711d29d2ac
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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