4-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidine → HCID 22732415, compound

HRID 1765263Notes

Reaction equation

HRID 1765263 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1.[F:18][C:19]([F:26])([F:25])[C:20]1[CH:24]=[CH:23][NH:22][N:21]=1>>[F:18][C:19]([F:26])([F:25])[C:20]1[CH:24]=[CH:23][N:22]([C:2]2[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]3[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=3)[N:3]=2)[N:21]=1

Participants

3

Reactant 2

HCID 14859904-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidineHCID 18070343-(Trifluoromethyl)pyrazole

Product 1

HCID 22732415HCID 22732415, compound

Procedure

The title compound was prepared from 4-chloro-2-(3-pyridinyl)-6-trifluoromethyl-pyrimidine (74 mg, 0.285 mmol) and 3-trifluromethyl-pyrazol (48 mg, 0.353 mmol) similar to Example 166 and was isolated as a white solid (mp 139–140° C., 53 mg, 0.148 mmol, 52%). 1H NMR (CDCl3): 9.73 (s, 1H), 8.82 (m, 3H), 8.26 (s, 1H), 7.50 (m, 1H), 6.87 (d, J=2.7 Hz, 1H).

Sources & evidence

ORD record
ord-624d360d9b604e3dabde100df123e32b
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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