4,5-Dihydro-2-thiazolamine → HCID 22732418, compound

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Reaction Steps

The title compound was prepared from 4-chloro-2-(3-pyridinyl)-6-trifluoromethyl-pyrimidine (75 mg, 0.289 mmol) and 2-amino-2-thiazoline (37 mg, 0.362 mmol) similar to Example 166 and was isolated as a white solid (20 mg, 0.61 mmol, 21%). 1H NMR (CDCl3/MeOH-d4) 9.45 (s, 1H), 8.73 (dt, 1.8, 8.1 Hz, 1H), 8.58 (dd, J=1.8, 5.1 Hz, 1H), 7.47 (m, 1H), 6.70 (s, 1H), 3.93 (t, J=6.6 Hz, 2H), 3.04 (t, J=7.2 Hz, 2H).

Provenance & Evidence