4-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidine → HCID 178506229, compound

HRID 1765267Notes

Reaction equation

HRID 1765267 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1.[NH2:18][C:19]1[CH:23]=[CH:22][NH:21][N:20]=1>>[NH:21]1[CH:22]=[CH:23][C:19]([NH:18][C:2]2[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]3[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=3)[N:3]=2)=[N:20]1

Participants

3

Reactant 2

HCID 14859904-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidineHCID 178418806HCID 178418806, compound

Product 1

HCID 178506229HCID 178506229, compound

Procedure

The title compound was prepared from 4-chloro-2-(3-pyridinyl)-6-trifluoromethyl-pyrimidine (75 mg, 0.289 mmol) and 3-amino pyrazole (31 mg, 0.373 mmol) similar to Example 166 and was isolated as a white solid (mp 230° C. decompose, 31 mg, 0.101 mmol, 35%). 1H NMR (DMSO-d6) 9.62 (d, J=1.2 Hz, 1H), 8.77 (m, 3H), 7.71 (s, 1H), 7.62 (dd, J=4.5, 7.5 Hz, 1H), 6.09 (d, J=3 Hz, 1H), 5.89 (s, 1H).

Workup

  1. customwas isolated as a white solid (mp 230° C. decompose, 31 mg, 0.101 mmol, 35%)

Sources & evidence

ORD record
ord-58a0b7d546a54d40ae89aebbf58e1a89
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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