2-Amino-4-isopropylphenol → HCID 135794343, compound

HRID 1765286Notes

Reaction equation

HRID 1765286 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[N:3]=1.[OH:18][C:19]1[CH:25]=[CH:24][C:23]([CH:26]([CH3:28])[CH3:27])=[CH:22][C:20]=1[NH2:21]>>[OH:18][C:19]1[CH:25]=[CH:24][C:23]([CH:26]([CH3:28])[CH3:27])=[CH:22][C:20]=1[NH:21][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[N:3]=1

Participants

3

Reactant 2

HCID 6624402-Amino-4-isopropylphenolHCID 113115004-Chloro-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine

Product 1

HCID 135794343HCID 135794343, compound

Procedure

The title compound was prepared from 4-chloro-2-(2-pyridinyl)-6-trifluoromethylpyrimidine (40 mg, 0.154 mmol) and 2-hydroxy-5-isopropylaniline (35 mg, 0.231 mmol) similar to Example 185 and was isolated as a solid (32 mg, 55%). 1H NMR (DMSO-d6): 8.74 (s, 1H), 8.73 (d, J=0.9 Hz, 1H), 8.35 (d, J=7.8 Hz, 2H), 7.95 (t, J=8.1 Hz, 2H), 7.54 (m, 2H), 6.60 (m, 2H), 2.78 (sep, J=6.9 Hz, 1H), 1.20 (d, J=6.9 Hz, 6H).

Sources & evidence

ORD record
ord-2c924ba8b7544a39900846efb8642740
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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