2,5-Dimethylaniline → HCID 22732473, compound

HRID 1765290Notes

Reaction equation

HRID 1765290 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[N:16][CH:15]=[CH:14][N:13]=2)[N:3]=1.[CH3:18][C:19]1[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][C:20]=1[NH2:21]>>[CH3:18][C:19]1[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][C:20]=1[NH:21][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[N:16][CH:15]=[CH:14][N:13]=2)[N:3]=1

Participants

3

Reactant 2

HCID 72592,5-DimethylanilineHCID 227323674-Chloro-2-(2-pyrazinyl)-6-(trifluoromethyl)pyrimidine

Product 1

HCID 22732473HCID 22732473, compound

Procedure

The title compound was prepared similar to 4-chloro-2-(2-pyrazinyl)-6-trifluoromethylpyrimidine (30 mg, 0.115 mmol) and 2,5-dimethylaniline (21 mg, 0.172 mmol) similar to Example 180 and was isolated as an off white solid (35 mg, 80% yield). 1H NMR (CDCl3): 9.74 (d, J=1.5 Hz, 1H), 8.76 (dd, J=1.5, 2.4 Hz, 1H), 8.71 (d, J=2.4 Hz, 1H), 7.48 (brs, 1H), 7.22 (d, J=8.1 Hz, 1H), 7.12 (m, 2H), 6.65 (s, 1H), 2.36 (s, 3H), 2.23 (s, 3H).

Sources & evidence

ORD record
ord-2a551c46d8ec4b9aaaf07a9ed6d33db5
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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