3-Amino-4-isopropylphenol → HCID 69461023, compound

HRID 1765293Notes

Reaction equation

HRID 1765293 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[N:16][CH:15]=[CH:14][N:13]=2)[N:3]=1.[OH:18][C:19]1[CH:20]=[CH:21][C:22]([CH:26]([CH3:28])[CH3:27])=[C:23]([CH:25]=1)[NH2:24]>>[OH:18][C:19]1[CH:20]=[CH:21][C:22]([CH:26]([CH3:28])[CH3:27])=[C:23]([CH:25]=1)[NH:24][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[N:16][CH:15]=[CH:14][N:13]=2)[N:3]=1

Participants

3

Reactant 2

HCID 36141583-Amino-4-isopropylphenolHCID 227323674-Chloro-2-(2-pyrazinyl)-6-(trifluoromethyl)pyrimidine

Product 1

HCID 69461023HCID 69461023, compound

Procedure

The title compound was prepared from 4-chloro-2-(2-pyrazinyl)-6-trifluoromethylpyrimidine (30 mg, 0.115 mmol) and 5-hydroxy-2-isopropylaniline (26 mg, 0.173 mmol) similar to Example 190 and was isolated as a solid. 1H NMR (CDCl3): 9.75 (d, J=1.2 Hz, 1H), 8.77 (t, J=1, 8 Hz, 1H), 8.72 (d, J=2.7 Hz, 1H), 7.29 (brs, 1H), 7.27 (s, 1H), 6.91 (dd, J=8.4, 2.4 Hz, 1H), 6.79 (d, J=2.7 Hz, 1H), 6.70 (s, 1H), 4.13 (sep, J=6.9 Hz, 1H), 1.20 (d, J=6.9 Hz, 6H).

Workup

  1. customwas isolated as a solid

Sources & evidence

ORD record
ord-fa8a91bb69bb41278bced5bfedd34aa8
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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