2,6-Dimethoxypyridin-3-amine → HCID 22732430, compound

HRID 1765300Notes

Reaction equation

HRID 1765300 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1.[NH2:18][C:19]1[C:20]([O:27][CH3:28])=[N:21][C:22]([O:25][CH3:26])=[CH:23][CH:24]=1>>[CH3:28][O:27][C:20]1[C:19]([NH:18][C:2]2[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]3[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=3)[N:3]=2)=[CH:24][CH:23]=[C:22]([O:25][CH3:26])[N:21]=1

Participants

3

Reactant 2

HCID 5930052,6-Dimethoxypyridin-3-amineHCID 14859904-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidine

Product 1

HCID 22732430HCID 22732430, compound

Procedure

The title compound was prepared from 4-chloro-2-(3-pyridinyl)-6-trifluoromethylpyrimidine (50 mg, 0.192 mmol) and 3-amino-2,6-dimethoxypyridine (44 mg, 0.288 mmol) similar to Example 180 and was isolated as a yellow solid (15 mg, 20%). 1H NMR (CDCl3): 9.62 (brs, 1H), 8.72–8.67 (m, 2H), 7.42 (dd, J=8.1, 5.4 Hz, 1H), 7.09 (s, 1H), 6.75 (s, 1H), 6.43 (d, J=8.7 Hz, 1H), 4.08 (s, 3H), 4.02 (s, 3H).

Sources & evidence

ORD record
ord-df82b66c584a4e4c867ac59a7eb6c08f
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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