4-Amino-1,2,4-triazole → HCID 22732461, compound

HRID 1765305Notes

Reaction equation

HRID 1765305 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:3]=1.[NH2:18][N:19]1[CH:23]=[N:22][N:21]=[CH:20]1>>[N:19]1([NH:18][C:2]2[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]3[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=3)[N:3]=2)[CH:23]=[N:22][N:21]=[CH:20]1

Participants

3

Reactant 2

HCID 114324-Amino-1,2,4-triazoleHCID 14859904-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidine

Product 1

HCID 22732461HCID 22732461, compound

Procedure

The title compound was prepared from 4-chloro-2-(3-pyridinyl)-6-trifluoromethylpyrimidine (50 mg, 0.192 mmol) and 1-amino-1,3,4-triazole (24 mg, 0.288 mmol) similar to Example 190 and was isolated as a solid. 1H NMR (CDCl3): 9.61 (brs, 1H), 8.71–8.66 (m, 4H), 7.41 (m, 2H), 6.69 (s, 1H), 5.18 (s, 2H).

Workup

  1. customwas isolated as a solid

Sources & evidence

ORD record
ord-ea25d79d962c4d469e0b963738e3eddf
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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