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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1765309Generated: October 31, 2026

Phenol, 5-amino-2,4-dichloro- → HCID 22732498, compound

https://huagongshe.com/reaction/1765309

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhenol, 5-amino-2,4-dichloro-HCID 101471—
Reactant4-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidineHCID 1485990—
ProductHCID 22732498HCID 22732498—

Reaction Steps

The title compound was prepared from a mixture of 4-chloro-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine (50 mg, 0.193 mmol) and 5-amino-2,4-dichlorobenzenol (51 mg, 0.289 mmol) similar to Example 117 and isolated as a white solid (24 mg, 31%). 1H NMR (DMSO-d6): 10.80 (s, 1H), 9.90 (s, 1H), 9.39–9.38 (m, 1H), 8.75–8.72 (m, 1H), 8.57–8.53 (m, 1H), 7.63 (s, 1H), 7.61 (s, 1H), 7.59–7.55 (m, 1H), 7.31 (s, 1H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07226927B2
Source datasetuspto-grants-2007_06
ORD IDord-a32b4458132f4f7b93df32590dd2a35b
Source noteuspto-grants-2007_06