Methyl iodide → 7-Methylsulfanyl-2-isopropyl-4-bromo-2H-phthalazin-1-one

Participants

Reaction Steps

To a solution of 7-Mercapto-2-isopropyl-4-bromo-2H-phthalazin-1-one (0.77 g, 2.6 mmol) in tetrahydrofuran (THF) (8 ml), was added NaH (60%, 0.13 g, 3.1 mmol) portion-wise. After stirring for five minutes, methyl iodide (0.44 g, 3.1 mmol) was added dropwise and stirring was continued for four hours. The mixture was concentrated under vacuum and the residue was subjected to flash column chromatography (elution: 90% heptane, 10% ethyl acetate) to give the title compound (0.44 g, 54% yield) as a white solid.

Provenance & Evidence