Methyl iodide → HCID 68896686, compound

Participants

Reaction Steps

1-[tert-Butoxycarbonyl-(1-tert-butoxycarbonyl-5-methyl-1H-pyrazol-3-yl)-amino]-3-isopropyl-4-oxo-3,4-dihydro-phthalazine-6-carboxylic acid (10 mg, 0.019 mmol) (Intermediate of Example M-1) was dissolved in dichloromethane (DCM) (1 ml). To this was added K2CO3 (3.1 mg, 0.028 mmol) followed by methyl iodide (3.3 mg, 0.028 mmol) and the reaction mixture was stirred at room temperature for 30 minutes. After this time the reaction mixture was partitioned between ethyl acetate (10 ml) and water (10 ml). The organic layer was separated, dried (MgSO4), filtered and concentrated under vacuum.

Provenance & Evidence