HCID 21106545, compound → HCID 21106535, compound

HRID 1765368Notes

Reaction equation

HRID 1765368 reaction equation
Br[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5](=[O:12])[N:4]([C:13]2[CH:18]=[CH:17][C:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[CH3:25])=[CH:15][CH:14]=2)[N:3]=1.[C:26]([N:30]1[C:34]([CH3:35])=[CH:33][C:32]([NH2:36])=[N:31]1)([CH3:29])([CH3:28])[CH3:27]>>[C:26]([N:30]1[C:34]([CH3:35])=[CH:33][C:32]([NH:36][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5](=[O:12])[N:4]([C:13]3[CH:18]=[CH:17][C:16]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=4[CH3:25])=[CH:15][CH:14]=3)[N:3]=2)=[N:31]1)([CH3:29])([CH3:28])[CH3:27]

Participants

3

Reactant 2

HCID 21106545HCID 21106545, compoundHCID 451212361H-Pyrazol-3-amine, 1-(1,1-dimethylethyl)-5-methyl-

Product 1

HCID 21106535HCID 21106535, compoundYield 31%

Procedure

4-Bromo-2-(2′-methyl-biphenyl-4-yl)-2H-phtalazin-1-one (prepared from the appropriate starting materials in analogy to Method Q-1) was coupled with 1-tert-butyl-5-methyl-1H-pyrazol-3-ylamine in a Buchwald reaction as described in Method O to give the title compound (0.049 g, 31% yield). 1H-NMR: (400 MHz, D6-DMSO) 8.44 (1H, s), 8.40 (1H, d), 8.33 (1H, d), 8.05 (1H, t), 7.97 (1H, t), 7.62 (2H, d), 7.40 (2H, d), 7.30 (2H, d), 7.24 (2H, d), 6.00 (1H, s), 2.28 (3H, s), 2.12 (3H, s), 1.57 (9H, s); MS (ESI+)=464.36 (M+H)+.

Sources & evidence

ORD record
ord-6b6bc2871e564ca78fbf340c159b3f16
Source dataset
uspto-grants-2007_06
Patent number
US07226923B2

Reaction notes

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