Phosphorus oxybromide → 4-Bromo-2-[3-(trifluoromethyl)phenyl]-1(2H)-phthalazinone

Participants

Reaction Steps

4-Hydroxy-2-(3-trifluoromethylphenyl)-2H-phthalazin-1-one (0.50 g, 1.6 mmol) and phosphorus oxybromide (1.9 g, 6.5 mmol) were stirred at 150° C. for 2 h. H2O (100 ml) was added after cooling to room temperature. The precipitated solid was collected by filtration and washed with H2O. Drying of the solid in vacuum gave the title compound (0.4 g, 66% yield). 1H-NMR: (400 MHz, D6-DMSO) 8.39 (1H, d), 7.95–8.12 (5H, m), 7.79–7.99 (2H, m); MS (ESI+)=370.98 (M+H)+.

Provenance & Evidence